Dr. Lars Olov Bygren, a preventive-health specialist who is now at the prestigious Karolinska Institute in Stockholm, began to wonder what long-term effects the feast and famine years might have had on children growing uphe showed that the grandsons of Overkalix boys who had overeaten died an average of six years earlier than the grandsons of those who had endured a poor harvest
The remote, snow-swept expanses of northern Sweden -Norrbotten is so isolated that in the 19th century, if the harvest was bad, people starved. The starving years were all the crueler for their unpredictability. For instance, 1800, 1812, 1821, 1836 and 1856 were years of total crop failure and extreme suffering. But in 1801, 1822, 1828, 1844 and 1863, the land spilled forth such abundance that the same people who had gone hungry in previous winters were able to gorge themselves for monthsIn 1986, for example, the Lancet published the first of two groundbreaking papers showing that if a pregnant woman ate poorly, her child would be at significantly higher than average risk for cardiovascular disease as an adult.
The answer lies beyond both nature and nurture. Bygren's data — along with those of many other scientists working \separately over the past 20 years — have given birth to a new science called
epigenetics:-
epigenetics is the study of changes in gene activity that do not involve alterations to the genetic code but still get passed down to at least one successive generation.These patterns of gene expression are governed by the cellular material — the epigenome — that sits on top of the genome, just outside it (hence the prefix epi-, which means above). It is these epigenetic "marks" that tell your genes to switch on or off, to speak loudly or whisper. It is through epigenetic marks that environmental factors like diet, stress and prenatal nutrition can make an imprint on genes that is passed from one generation to the next.
{Read more: http://www.time.com/time/health/article/0,8599,1951968,00.html#ixzz0cRlTlf0i}
{Read more: http://www.time.com/time/health/article/0,8599,1951968,00.html#ixzz0cRlTlf0i}
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